【中文题名】 慢性肾衰肾性贫血中促红细胞生成素受体的变化及意义 【英文题名】 Study of Erythropoietin Receptor in Renal Anemia Associated with Chronic Renal Failure 【中文摘要】 目的：探讨促红细胞生成素受体(EPOR)在慢性肾功能衰竭肾性贫血中的表达及意义。 方法：通过流式细胞仪技术检测30例慢性肾功能衰竭患者、12例透析患者、15例对照组(肾功能正常且无贫血)患者的外周血单个核细胞表面EPOR的表达。 结果：重度肾性贫血患者外周血单个核细胞表面EPOR表达(7.06±5.48)％显著高于轻中度肾性贫血组(3.51±1.73)％(p＜0.05)。慢性肾衰早期组外周血单个核细胞表面EPOR(5.36±3.15)％较对照组(2.12±1.75)％升高(p＜0.01)。尿毒症透析组外周血单个核细胞表面EPOR(0.92±1.23)％较尿毒症非透析组(3.48±2.79)％显著降 【英文摘要】 Objective: To study the use of erythropoietin receptor (EPOR) in anemia of chronic renal failure. Methods: A total of 57 patients were enrolled in this study. The expressions of EPOR on peripheral blood mononuclear cells(PBMCs) were measured by flow cytometry in 30 patients with chronic renal failure(CRF) , 12 dialysis patients ,15 control patients (with normal renal function and without anemia) . Results: The expressions of EPOR on PBMCs in patients with severe renal anemic ( 7.06 5.48 ) % were increa 【中文关键词】 促红细胞生成素受体. 肾功能衰竭. 慢性. 贫血. 【英文关键词】 erythropoietin receptor. kidney failure. chronic. anemia. 引言 7-8 一、 对象与方法 8-10 二、 结果 10-16 三、 讨论 16-019 参考文献 019-21 综述 21-32 致谢 32-32